HPMC wird durch den durchschnittlichen Substitutionsgrad (DS) sowie das Verhältnis Methyl vs. Hydroxypropyl charakterisiert.[9] In Verbindung mit der allgemeinen Bezeichnung „Hypromellose“ wird dies durch eine vierstellige Zahl symbolisiert, wobei die ersten zwei dem Methoxy-Gehalt entsprechen, die letzten zwei dem Hydroxypropoxy-Gehalt.[10]
In conclusion, HPMC is a versatile and widely used pharmaceutical excipient that offers a range of benefits for formulators. Its ability to form gels, excellent film-forming capabilities, and compatibility with a wide range of drugs make it an invaluable tool in the development of safe and effective drug products. As the demand for pharmaceuticals continues to grow, the role of HPMC is likely to become even more important in the future. Furthermore, HPMC dispersion is also known for its excellent solubility in water. This means that it can be easily incorporated into a variety of formulations without the need for additional solvents. This makes it a convenient and environmentally friendly choice for manufacturers looking to create products with a clean label. The substitution pattern in HPMC can vary, typically involving methoxy (-OCH3) groups at the 2 and 6 positions of the glucose ring and hydroxypropyl (-OCH2CH(OH)CH3) groups at the 2 position. This substitution not only increases the solubility of the cellulose in water but also influences its viscosity, stability, and interaction with other substances. The viscosity of a solution containing HEC is dependent on several factors, including the concentration of HEC, the molecular weight of the polymer chains, and the temperature of the solution. Higher concentrations of HEC and longer polymer chains typically result in a thicker solutionThese are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
3. Reduced Costs By minimizing errors and streamlining workflows, HPMC helps businesses reduce operational costs. This includes savings on shipping, handling, and administrative expenses.The approach followed by the FEEDAP Panel to assess the safety and the efficacy of HPMC is in line with the principles laid down in Regulation (EC) No 429/20087 and the relevant guidance documents: Guidance on technological additives (EFSA FEEDAP Panel, 2012a), Guidance on studies concerning the safety of use of the additive for users/workers (EFSA FEEDAP Panel, 2012b), Guidance on the identity, characterisation and conditions of use of feed additives (EFSA FEEDAP Panel, 2017a), Guidance on the assessment of the safety of feed additives for the target species (EFSA FEEDAP Panel, 2017b), Guidance on the assessment of the safety of feed additives for the consumer (EFSA FEEDAP Panel, 2017c), Guidance on the assessment of the efficacy of feed additives (EFSA FEEDAP Panel, 2018) and Guidance on the assessment of the safety of feed additives for the environment (EFSA FEEDAP Panel, 2019).
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