≤14
Genotoxicity refers to the ability of a chemical substance to damage DNA , the genetic material of cells. As genotoxicity may lead to carcinogenic effects, it is essential to assess the potential genotoxic effect of a substance to conclude on its safety.
For the Year 2020
Key benefits for stakeholders
No. The titanium dioxide we use in our toothpastes has been proven safe by health experts around the world. It is used in our toothpastes as a white colourant, in a non-nano form as defined by European regulations. It is an approved colourant in cosmetics, and we comply with all the regulations applicable to it.
China's Dominance in Titanium Dioxide Production and Its Impact on the Global Market What is Ponceau 4R? Together, these two ingredients form a powerful team in the world of cosmetics. They work synergistically to provide a range of benefits that include improved skin texture, enhanced UV protection, and a natural-looking matte finish. This combination is particularly popular in foundations, concealers, and powders, where it is used to create a flawless and long-lasting base This combination is particularly popular in foundations, concealers, and powders, where it is used to create a flawless and long-lasting baseIn order to contribute with experimental evidence that could help to achieve a better understanding of the field for future regulation, in the present work, the biocompatibility of commercial P25TiO2NPs (one type of TiO2NPs used in sunscreen formulations) and two novel functionalized P25TiO2NPs were evaluated under solar simulated irradiation. White light, generated by red, blue, and yellow LEDs, together with UV ones, was chosen to simulate the solar spectra. Functionalization of TiO2NPs was made with antioxidant vitamins in order to prevent the expected photo-initiated ROS production when nanoparticles are exposed to the simulated solar spectra. Vitamin B2 (riboflavin) and vitamin C were chosen to carry out the functionalization because they are water-soluble, low-cost, and are a constitutive part of biological processes. In addition, it is known that both have the potential to prevent macromolecular oxidation by ROS [23], [24], [25], [26].
In conjunction with Ponceau 4R, the factory also produces Titanium Dioxide, a versatile pigment known for its brilliant white hue and exceptional opacifying properties. It is widely used in paints, plastics, paper, and textiles. The manufacture of Titanium Dioxide here involves advanced chemistry techniques that transform raw ore into a fine, consistent pigment suitable for myriad industrial uses.
The toxicity of P25TiO2NPs under UV radiation could be even higher when combined with other usual components of sunscreens Indeed, Soler de la Vega et al. advise that combination with parabens increases the toxicity of the final cosmetic mixture [53].
Color, compared with standard samples
Nano, or ultrafine, TiO2 comprises primary particles sized less than 100nm. In this grade, titanium dioxide is transparent (colourless) and boasts improved UV scattering and absorbing properties compared with larger particle-size pigmentary TiO2.
EINECS: 215-715-5
In summary, the Food Directorate's position is that there is no conclusive scientific evidence that the food additive TiO2 is a concern for human health. This is based on a review of the available scientific data relevant to food uses of TiO2. However, we will continue to monitor the emerging science on the safety of TiO2 as a food additive and may revisit our position if new scientific information becomes available.
Safety Concerns and Regulations Lanxess is a German chemical company that offers a comprehensive range of precipitated barium sulfate products. With a focus on innovation and sustainability, Lanxess has been able to maintain its position as a top supplier in the market. Their products are widely used in the rubber, plastics, and coatings industries due to their excellent properties.Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”
Anatase titanium dioxide, with its 98% purity, offers a range of benefits that make it an ideal choice for paint formulations. Its unique crystal structure imparts excellent ultraviolet (UV) resistance, which safeguards painted surfaces from fading and degradation over time. Furthermore, its high refractive index contributes to exceptional hiding power and gloss retention, enhancing the aesthetic appeal of coatings.