Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”
Titanium Dioxide (TiO2), specifically in its anatase form, is widely recognized for its high refractive index and excellent pigment properties. When used in paints, it not only provides brightness and opacity but also ensures excellent durability and resistance to discoloration. These attributes are paramount in creating paints that maintain their vibrancy over time, even under harsh environmental conditions.
The gastrointestinal tract is a complex barrier/exchange system, and is the most important route by which macromolecules can enter the body. The main absorption takes place through villi and microvilli of the epithelium of the small and large intestines, which have an overall surface of about 200 m2. Already in 1922, it was recognized by Kumagai, that particles can translocate from the lumen of the intestinal tract via aggregation of intestinal lymphatic tissue (Peyer’s patch, containing M-cells (phagocytic enterocytes)). Uptake can also occur via the normal intestinal enterocytes. Solid particles, once in the sub-mucosal tissue, are able to enter both the lymphatic and blood circulation.
Nano, or ultrafine, TiO2 comprises primary particles sized less than 100nm. In this grade, titanium dioxide is transparent (colourless) and boasts improved UV scattering and absorbing properties compared with larger particle-size pigmentary TiO2.
It should also be considered that due to the low pH in the stomach, the increased dissolution of the TiO2 particles may increase its bioavailability and may facilitate the entry of titanium ions into the blood circulation. Despite the relatively large consumption of TiO2 as a food additive, no studies on the effect of pH on its absorption and bioavailability have been found in the literature. This can be attributed to a general belief that TiO2is completely insoluble. However, this is not completely true, as TiO2 particles show a certain degree of solubility.
Titanium dioxide, also known as TiO2, is a white inorganic compound that has a wide range of applications in various industries. One of the most significant uses of titanium dioxide is as a pigment in paints, plastics, and paper. The price per kilogram of titanium dioxide varies depending on several factors, including the quality, purity, and production method.
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