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It should also be considered that due to the low pH in the stomach, the increased dissolution of the TiO2 particles may increase its bioavailability and may facilitate the entry of titanium ions into the blood circulation. Despite the relatively large consumption of TiO2 as a food additive, no studies on the effect of pH on its absorption and bioavailability have been found in the literature. This can be attributed to a general belief that TiO2is completely insoluble. However, this is not completely true, as TiO2 particles show a certain degree of solubility.

Fig One of the most promising applications of TiO2 in medicine is its use as a drug delivery system. Due to its biocompatibility and ability to encapsulate drugs, TiO2 nanoparticles can be engineered to release medication slowly over time, improving treatment efficacy and reducing side effects. This technology has been explored extensively in China for targeted drug delivery in treating diseases like cancer and diabetes. Thirdly, titanium dioxide is a semiconductor material with a wide bandgap energy of 3

Safety

Though the Food and Drug Administration (FDA) categorizes titanium dioxide as Generally Recognized as Safe (8), other organizations have issued warnings.

Rutile Titanium Dioxide R6618

Partial substitution of titanium dioxide in liquid paints 

Titanium Oxide Rutile Manufacturers Pioneering Innovation in the Industry
When combined, mica and titanium dioxide in shampoo can create a synergistic effect, enhancing each other's benefits
 

In 2022, a year after the EFSA recommended against the use of E171, the Food Standards Australia New Zealand (FSANZ) conducted its own reassessment of titanium dioxide as a food additive. The agency concluded that titanium dioxide was indeed safe to use as a food additive. The United Kingdom and Canada came to similar conclusions.

  • through our respiratory tract by breathing. 
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