Data on chronic toxicity and carcinogenicity are available for microcrystalline cellulose (E 460), methyl cellulose (E 461) hydroxypropyl cellulose (E 463), HPMC (E 464) and sodium carboxymethyl cellulose (E 466). Some studies were unfit for evaluation due to methodological shortcomings. In the only relevant study, the dietary administration of even high doses of microcrystalline cellulose (E 460) (30%, 15,000 mg/kg bw) to rats for 72 weeks did not affect survival, feed efficiency or haematology. Apart from some dystrophic calcification in renal tubules, no other relevant lesions were noted and tumour incidence did not differ with that of controls. Several studies were conducted in rats with methyl cellulose (E 461) via feed or drinking water or by gavage at concentrations up to 5% (2,500 mg methyl cellulose/kg bw per day) and for up to 2 years. For all examined parameters, no adverse effects were reported and also the observed tumours did not differ in type and number in treated and control groups. In the only identified study, the daily dosing of male and female rats (0, 1,500, 3,000 or 6,000 mg hydroxypropyl cellulose/kg bw) via gavage for 6 months did not cause adverse effects (including carcinogenicity) apart from a decrease in body weight in high-dosed rats (statistically significant in females only). Apart from a decrease in body weights of high-dosed males, no other significant adverse findings were reported and there was no indication of a carcinogenic effect in rats of either sex dietary exposed to HPMC (E 464) up to 20% (10,000 mg/kg bw per day) for 1 year. Carboxy methylcellulose (E 466) was tested in mice and rats at dosages of 0, 10,000 or 100,000 mg/kg diet (equivalent to 0, 1,500 or 15,000 mg/kg bw per day for mice and to 0, 500 or 5,000 mg/kg bw per day for rats) for up to 104 weeks. Despite the increase in feed intake, a treatment related decrease in body weight was noted at the end of the treatment. Histological examination revealed no intestinal abnormality or evidence of the passage of the additive across the intestinal wall in either species and the tumour incidences were comparable among groups.
The primary use of redispersible powder lies in the construction industry, particularly in the production of building materials like mortars, plasters, and adhesives. It acts as a bonding agent, enhancing the cohesion, flexibility, and durability of these materials. Its inclusion improves the workability, water resistance, and freeze-thaw stability of concrete, making structures more robust and resilient against environmental conditions. When it comes to buying HPMC, the first step is to determine your specific requirements. Different grades of HPMC are available, each tailored for specific applications. For instance, pharmaceutical grade HPMC is highly purified and used in tablet coatings and controlled drug release systems, while construction grade HPMC is used as a binder in plaster and mortar.6. Agricultural sector:
The HS code for redispersible polymer powder falls under the category of polymers of ethylene, in primary forms. This code helps customs officials and traders to accurately identify, classify, and track the movement of redispersible polymer powder across countries and regions. It is essential for importers and exporters to know the correct HS code for their product to ensure smooth customs clearance and compliance with international trade regulations. **Conclusion In conclusion, the solubility of HPMC in water is a fundamental aspect that defines its utility across diverse sectors. Whether it's pharmaceuticals, construction, food, or coatings, HPMC's ability to dissolve effectively in water and form gels makes it an indispensable ingredient with a wide range of functionalities. In the field of paints and coatings, redispersible polymer powder is used to improve the adhesion, flexibility, and corrosion resistance of the coating. When added to paint, it forms a film that protects the underlying surface from environmental factors such as moisture, UV radiation, and chemicals. The polymer particles also help to level the coating surface, resulting in a smooth and uniform finish The polymer particles also help to level the coating surface, resulting in a smooth and uniform finish