Different dermal cell types have been reported to differ in their sensitivity to nano-sized TiO2 . Kiss et al. exposed human keratinocytes (HaCaT), human dermal fibroblast cells, sebaceous gland cells (SZ95) and primary human melanocytes to 9 nm-sized TiO2 particles at concentrations from 0.15 to 15 μg/cm2 for up to 4 days. The particles were detected in the cytoplasm and perinuclear region in fibroblasts and melanocytes, but not in kerati-nocytes or sebaceous cells. The uptake was associated with an increase in the intracellular Ca2+ concentration. A dose- and time-dependent decrease in cell proliferation was evident in all cell types, whereas in fibroblasts an increase in cell death via apoptosis has also been observed. Anatase TiO2 in 20–100 nm-sized form has been shown to be cytotoxic in mouse L929 fibroblasts. The decrease in cell viability was associated with an increase in the production of ROS and the depletion of glutathione. The particles were internalized and detected within lysosomes. In human keratinocytes exposed for 24 h to non-illuminated, 7 nm-sized anatase TiO2, a cluster analysis of the gene expression revealed that genes involved in the “inflammatory response” and “cell adhesion”, but not those involved in “oxidative stress” and “apoptosis”, were up-regulated. The results suggest that non-illuminated TiO2 particles have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes in extracellular matrix remodelling. In human keratinocytes, Kocbek et al. investigated the adverse effects of 25 nm-sized anatase TiO2 (5 and 10 μg/ml) after 3 months of exposure and found no changes in the cell growth and morphology, mitochondrial function and cell cycle distribution. The only change was a larger number of nanotubular intracellular connections in TiO2-exposed cells compared to non-exposed cells. Although the authors proposed that this change may indicate a cellular transformation, the significance of this finding is not clear. On the other hand, Dunford et al. studied the genotoxicity of UV-irradiated TiO2 extracted from sunscreen lotions, and reported severe damage to plasmid and nuclear DNA in human fibroblasts. Manitol (antioxidant) prevented DNA damage, implying that the genotoxicity was mediated by ROS.
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It's sort of ironic, maybe ironic is the wrong word, that the ingredient in paint that makes your kitchen shiny also makes your Hostess cupcakes shiny, Environmental Working Group's senior vice president of government affairs Scott Faber added.
In the plastics industry, Lithopone B311 powder serves as a filler, enhancing the mechanical properties of polymers. It improves the rigidity, dimensional stability, and thermal resistance of plastic products, extending their lifespan and performance. Furthermore, it can also be used in the production of rubber goods, providing improved tensile strength and reducing the overall cost. A paint pigment factory is a bustling hub of precision and innovation, where the journey from mineral or chemical compound to finished product is a testament to human ingenuity. The primary function of these factories is to extract, refine, and blend pigments, which are the substances responsible for giving paint its color. These pigments can be natural, derived from sources like clay, earth, or plants, or synthetic, created through chemical processes.Zns 28-30% Chemical Provide Lithopone Pigments Low Price
In addition to sunscreen, titanium IV oxide is also used in the production of paints. Titanium dioxide is a popular pigment in the paint industry because of its brightness and opacity. It provides excellent coverage and durability, making it an ideal choice for exterior and interior paints. Titanium dioxide is often used in white paints, but it can also be used to create a wide range of colors by mixing it with other pigments.
Anatase, known for its excellent photocatalytic activity, is primarily used in the production of advanced materials and environmental protection products. Its unique ability to break down pollutants under sunlight makes it an ideal choice for air purification and self-cleaning surfaces. On the other hand, Rutile, with its superior opacity and durability, is more commonly used in the coatings, plastics, and paper industries, providing a white pigment and UV protection.