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TiO2 pigment factories also focus on environmental sustainability and strive to minimize their environmental impact. They implement measures such as waste management, recycling, and the use of eco-friendly production processes to reduce their carbon footprint. Some factories also use renewable sources of energy, such as solar or wind power, to power their operations and reduce their dependence on fossil fuels.

Among the raw materials for coating production, titanium dioxide is more ideal, followed by lithopone. The covering power of lithopone is only that of titanium dioxide, and the price of lithopone is much lower than that of titanium dioxide, so lithopone still occupies a large market share.

In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.